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When all of these four linked pathways are performing well, a high ratio of NAD + to NADH is maintained

2019;63(7):885-894 Promsin P

Role of glutathione metabolism and glutathione-related antioxidant defense systems in hypertension

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis