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As a carrier of photoinduced metabolites that exhibit cytotoxicity, the EVs derived from aloe can lead to significant oxidative stress in melanoma cells, which can confirm the existence of intercellular communication and signal regulation ( 4.2.2 Antioxidant and anti-inflammatory effects PDEVs are rich in antioxidant enzymes (SOD, peroxidase) and small molecules (flavonoids, vitamins) to effectively remove excess reactive oxygen species (ROS) in the reproductive system (Tiwari et al., 2025