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L-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis

NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

Calcium, for example, has an upper limit of 2,000 mg per day for adults 51 and older including food, drink and supplements

doi: 10.1016/j.bbadis.2017.12.031 62 FallowfieldJAMizunoMKendallTJConstandinouCMBenyonRCDuffieldJSet al