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Recognition may lead to otherwise unsuspected diagnoses and, therefore, could make possible early intervention before irreversible damage has occurred

The ability of Protandim to activate the heme oxygenase (HO-1) promoter as a representative of the family ofphase2 enzymes was evaluated in an in vitro system of cultured human SH-FY-5Y cells transiently transfected with a genetic construct consisting of the human HO-1 promoter driving expression of Firefly luciferase

Particularly, introduction of hydroxyl or methoxy group into the 4-hydroxyphenyl moiety diminished or significantly reduced mushroom tyrosinase inhibition