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FIGURE 2 At the same time, WD repeat-containing protein 5 (WDR5), a core subunit of the mixed-lineage leukemia/SET-domain (MLL/SET) complex, which plays a crucial role in regulating global H3K4me3 levels during vertebrate development and hematopoiesis, was detected both in vitro and in vivo (Wysocka et al., 2005)