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The patients using both tend to be longevity-focused, productivity-oriented, and proactive about aging rather than reactive

When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

~3545% non-responder rate

A high level of MET amplification ( MET -to- CEP7 ratio of 5 on fluorescence in situ hybridization (FISH) or a 510-fold increase in MET copy number detected via NGS) has been used to distinguish tumours that are more likely to be MET-driven, based on the absence of co-occurring oncogenic drivers and response to MET-directed TKIs (highest in tumours with MET copy number 10) 112,114,118