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For a balanced view tailored to your knee, it helps to talk through the topic with a specialist knee surgeon in Sydney who can frame it around your diagnosis and recovery stage

However, the efficacy of GLP-1 RAs, especially on WL, can vary between individuals for example, even with subcutaneous semaglutide 2.4 mg once weekly (currently, the most efficacious approved GLP-1 RA monotherapy for chronic weight management), only 46% of people with overweight/obesity and T2D will achieve 10% WL and 68% will achieve an HbA1c 6.5% [19]

Similarly, there is risk in most studies of underreporting PDAC events due to ascertainment bias, because active surveillance is not typically performed in controlled trials or performed in routine clinical practice

These findings are from clinical trials with pharmaceutical-grade semaglutide under medical supervision