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Acknowledgements This work was supported by the Funds for Creative Research Groups (81421063) and the National Natural Science Foundation of China (81570399, 81270042, 30901208, and 81773735) and the Program for New Century Excellent Talents In Heilongjiang Provincial University (1254-NCET-012)

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With this study, we have found that people who smoke a pack a day develop an average of 150 extra mutations in their lungs every year, which explains why smokers have such a higher risk of developing lung cancer. Additionally, other organs were also affected and the study showed that a pack a day led to an estimated average 97 mutations in each cell in the larynx, 39 mutations for the pharynx, 23 mutations for the mouth, 18 mutations for the bladder, and 6 mutations in every cell of the liver each year