Zhang X, Tao W, Mak PY, Qi Y, Ma W, Wang J, Ruvolo V, Andreeff M , Carter BZ
It is generally accepted that in vitro studies with concentrations of active compounds beyond the IC50 concentration of 25 M for pure compounds and the IC50 of 100 g/mL for the extracts have no therapeutic significance because they could not be implemented in vivo and are not appropriate for further pharmaceutical development [272]
Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Studies document accelerated healing of gastric and duodenal ulcers, protection against NSAID-induced gastropathy, improvement of inflammatory bowel disease in animal models, and healing of intestinal anastomoses and fistulas