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Cardiovascular remodelling in coronary artery disease and heart failure

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Source: Ferrandiz-Pulido and Garcia-Patos,1 Levi et al,10 and Halevy et al.11 Doxycycline has antibiotic, anti-inflammatory, immunomodulatory, and collagenase properties

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Wabitsch et al ., 2022, "Natural history of obesity due to POMC, PCSK1, and LEPR deficiency and the impact of setmelanotide"

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Mechanistic exploration suggested that pamidronate and clodronate markedly inhibit IGF-1-induced HIF-1 protein accumulation and VEGF expression in breast cancer cells via the PI-3K/AKT/mTOR signaling pathway and ultimately eliminate IGF-1-induced tumor angiogenesis in vivo and in vitro (38)

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