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The authors have investigated three treatments to correct metabolic abnormalities which have demonstrated improvement in behavior and/or metabolism, namely the combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) to treat oxidative stress in an open-label study (James et al., 2009a

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10.1210/jc.2005-1392 Hero M, Wickman S, Dunkel L: Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty

Samples were collected at the same time from both test and control groups during 20072011