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It should be noted that this conclusion has limitations, due to the fact that intracellular water very likely contributed a fair portion of that fat-free mass that was gained

Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)

Certainly, taking the supplements for 6 weeks has been associated with weight loss and improved lipid profile and serum glucose

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