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When alterations in nutritional status or mitochondrial dysfunction induce changes in the NAD + /NADH and AMP/ATP ratios, the expression of the PGC-1 coactivator family of proteins increases, and these proteins interact with nuclear respiratory factor (NRF)1 and 2, thereby activating the phosphorylation of AMPK and upregulating mitochondrial gene expression, transcription and replication [38, 39]
187 In NAFLD patients, severe fibrosis (F3F4) patients show reduced abundance of anti-inflammatory species (such as Eubacterium ventriosum and Alistipes finegoldii ) and increased abundance of genera like Enterobacter and Klebsiella in feces
Rung JP, Carlsson A, Rydn Markinhuhta K, Carlsson ML