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Hepatocytes exposed to intermittent hypoxia transferred miR-421 to macrophages through exosomes to inhibit SIRT3 and contribute to macrophage M1 polarization

However, during a phase II study assessing its safety and tolerability in patients with prodromal AD (NCT00890890), adverse events including gastrointestinal issues and skin cancer were observed in the high-dose treatment group

Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH: Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells