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In a double-blind placebo-controlled study, participants consumed vitamin C combined with vitamin E for 8 days leading up to a sunburn exposure to determine the minimal erythemal dose (MED) or the threshold in which a sunburn would occur (52)

Selenium deficiency induced the expression of the chondrocyte hypertrophy marker gene type X collagen (COLX) in articular cartilage 64

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Experiments indicate that paeonol markedly impedes IL-1-induced ferroptosis and inflammation in chondrocytes, partly through the AMPK/Nrf2/GPX4 axis ( in vitro and in vivo to alleviate DMM-induced OA