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LXR agonists, such as RGX-104 and GW3965, reduce MDSC levels by activating the LXR/ApoE axis and reversing cholesterol transport, thereby improving the anti-tumor response of T cells in preclinical and clinical settings (NCT02922764) in various treatment-refractory tumors, resensitizing patients to anti-PD1 therapy (97)

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A 2024 pharmaceutical review in Pharmaceuticals raised concerns that VEGF and VEGFR2 pathway activation in patients with undetected cancers presents a plausible, though unconfirmed, oncological risk

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