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Acknowledgements The authors thank Gregory Conner PhD for his insightful guidance and expertise, Professor Marianne Geiser for her valuable comments in preparing the manuscript, Nathalie Baumlin for her technical assistance with HBE cell cultures and Mir Anwar for his assistance with the fluorescence immunohistochemistry micrographs

Nicotine is highly addictive, and withdrawal symptoms can be intense

Slime flux is caused by the infection of sapwood by several bacteria and is a problem with mature mesquites

One of our smokers said it well: "Once you go Smokin' G Turkish, you don't go back!" Love the aromatic unique flavor profile of a Turkish Blend, but are searching for a subtler experience