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4648 Causes of pyridoxine deficiency have been reviewed and include low dietary intake due to anorexia or impaired ability to ingest foods that are high in nutrient content

-Glutamyl transpeptidase, which is abundant on the apical surface of most transporting epithelia, including liver canalicular and bile ductular membranes, is the only enzyme that can initiate catabolism of GSH and GSH-containing molecules (e.g., GSSG, glutathione S -conjugates, and glutathione-complexes) under physiological conditions

All mice were housed under a 12 h light/dark cycle, with the temperature consistently maintained between 18 C and 23 C and the humidity kept at ~50%

iTRAQ Labeling and 2D-HPLC-MS/MS Analysis Each 200 g extract sample was prepared using standard digestion, reduction, and alkylation procedures prior to isobaric tag for relative and absolute quantitation (iTRAQ) labeling (Shevchenko et al., 2006)