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Light activity becomes possible for acute injuries

Nobiletin, functioning as a P-gp inhibitor, can suppress P-gp overexpression in lymphocytes in the AIA rat model when co-administered through a nanodelivery system, providing novel insights for refractory RA (26, 198)

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In a similar model, rats supplemented with zinc had a significant reduction in opened tight junctions when compared with untreated rats with colitis, but no amelioration of clinical disease [157]