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Nicotine activates an increased amount of osteoclast cells that deteriorate the bone progressively and inhibits the differentiation of osteoblasts (bone-forming cells) as well as mesenchymal stem cells in the bone marrow (the stem cell source of our body mainly responsible for producing bone, cartilage, and fat also known as MSC'S)

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Nicotine may be found in various items, including cigarettes, cigars, chewing tobacco, and other forms of snuff