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CJC-1295 extends the GH pulse duration by preventing rapid degradation of growth hormone-releasing hormone (GHRH), meaning Ipamorelin's pulse amplitude gets amplified and prolonged when both are active simultaneously

Clinical data with epacadostat (investigational drug for cancer inhibiting IDO1 an immune modulating enzyme indoleamine -2,3-dioxygenase-1) showed that hydroxyamidine based inhibitors are extensively glucuronidated in humans