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In both models, levels of thiomethyl metabolites were low (normalised area of S-CH3-APAP-S and SO-CH3-APAP-S represent less than 3 and 1% in PHH and HRG of all detected metabolites areas, respectively) compared to direct phase II conjugates (Fig

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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

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