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ROS ROS are signalling molecules composed of oxygen-containing reactive entities such as the superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), the hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ), and primarily originate from electron leakage in the mitochondrial electron transport chain [10]

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312 Furthermore, endothelial cells respond to hyperuricemia by upregulating angiotensin-converting enzyme activity, which enhances angiotensin II and superoxide anion production