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TB-500 reduces production of pro-inflammatory cytokines at injury sites, creating a more permissive environment for nerve regeneration

Al fijarse al dominio extracelular, provoca autofosforilacin de residuos de tirosina y reclutamiento de sustratos IRS-1/IRS-2, disparando dos rutas principales: la va PI3K/Akt, asociada a supervivencia celular, captacin de glucosa e inhibicin de la apoptosis, y la va MAPK/ERK, vinculada a proliferacin y crecimiento

Effect of acetaminophen on glutathione levels in rat testis and lung. Environmental Health Perspectives 1994, 102 (Supplement 9): 63-64.

Scientists isolated this particular 15-amino-acid sequence (hence "157") because it retains the protective properties of the full protein while being more stable and easier to synthesise