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Newly synthesised heme may also not be exposed to the cytoplasm on leaving the mitochondria, instead achieving transfer either by inter-organellar transport via vesicles or by heme transfer during direct contact between inter-organellar membranes (Severance and Hamza 2009)

The fact is that our diet usually contains plenty of cysteine and the other sulphur-containing amino acid methionine, which is readily converted into cysteine in the liver [1]