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16,77,78 These studies highlighted that CS was an exacerbating factor in uncontrolled cell proliferation and invasiveness of breast tumor cell lines, the pathogenesis of a subpopulation of CD44 + /CD49f + tumor stem cells, and the enhancement of metastasis from the primary injection site

In 1998, Reynolds, along with three other companies, agreed to begin paying billions of dollars to compensate states for having knowingly propelled a smoking epidemic, which by then had led to the deaths of about 20 million Americans

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1 2 3 Bonsack's cigarette machine Archived 2006-11-13 at the Wayback Machine U.S