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Current markers (e.g., GPX4 expression, 4-HNE, and serum creatinine) lack specificity for ferroptosis-driven cyst progression, as they are altered in other kidney diseases or metabolic disorders

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Clinical trial objectives The purpose of the clinical study in humans was to evaluate the efficacy of four weeks supplementation of a combination of vitamin B6, B9, B12, and taurine on motivated behavior, as a primary outcome, and on attentional performance, and self-reported mood (e.g., fatigue, vigor) as secondary outcomes

The comparison of docking and MD stable conformations helps to determine the stability of the complexes