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An in vivo experiment based on the acute HH mouse model has confirmed that prophylactic administration of tetrahydrocurcumin can alleviate acute HH-induced brain edema, reduce the levels of inflammatory factors IL-1 and TNF-, increase SOD activity to enhance hypoxia resistance, and inhibit the NF-B/VEGF/MMP-9 pathway to reduce HH-induced brain edema and inflammation, thereby exerting neuroprotective effects ( Curcuma longa and its active metabolites, through multi-target regulation of inflammatory responses and BBB protection, may provide a novel strategy for the pathological intervention of brain edema in hypoxic environments at high altitudes