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The long non-coding RNA MALAT1 suppresses NRF2 expression through epigenetic mechanisms, promoting inflammasome activation and ROS production in Parkinsons disease (PD) mouse and microglial cell models, thereby exacerbating neuroinflammation [168]

Indeed, all glial cell types have receptors for cannabinoids, which have wide ranging effects on cellular function, indicating that cannabis may be beneficial for glial regulation of myelination (Figure 2B