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Therefore, normal glomerular levels of HS are necessary for renal function in general and the control of glomerular permeability in particular (93, 108), and HS in small arterioles is necessary for the appropriate control of GFR (96) because it helps maintain the normal structure and function of blood vessels

Current efforts in disease-modifying therapies are increasingly focused on targeting alpha-synuclein (-Syn), the hallmark protein of PD

This stabilizes skin structure, slows collagen loss, and with continued use, improves texture and tone

However, the current evidence remains largely experimental , and robust human clinical trials are still needed before BPC-157 can be considered an established medical therapy