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The corresponding Hotelling T 2 value for female participants with ME/CFS was 150, ranking fifth after malate ( T 2 = 293), 3-methyl-2-oxobutyrate ( T 2 = 258), 4-methyl-2-oxopentanoate ( T 2 = 244), 3-methyl-2-oxovalerate ( T 2 = 209), and pantothenate/vitamin B 5 ( T 2 = 163)

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placebo), 12% (6 mg, p = 0.93 vs

Retatrutide sits comfortably in the middle, with a half-life similar to semaglutide and slightly longer than tirzepatide