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The follow-up 2023 systematic review by the same team covered 33 studies and 1,180 participants across 23 different growth factor preparations and concluded that topical growth factor application is effective for facial skin rejuvenation, particularly when delivery is enhanced [6]

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In research contexts, combinations of bioactive peptides such as BPC-157 , TB-500 , KPV , and GHK-Cu are of growing interest due to their individual and potentially synergistic effects on biological pathways involved in cellular repair , inflammation regulation , and tissue regeneration