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The results showed that the combination treatment of nicotine replacement and varenicline was indeed more effective for smoking cessation, with 44.3% of participants abstaining from smoking through the last weeks of the study

Chronic smoking also leads to the formation of atheromatous plaques due to increased expression of matrix metalloproteinases (MMP), particularly MMP-12 and MMP-9 in macrophages, MMP-8 and MMP-9 in endothelial cells, and MMP-2 and MMP-9 in vascular smooth muscle cells ( 35 , 36 )

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