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The genetic instrument for CSI comprised by 90 SNPs with independent and robust associations with the lifetime smoking exposure indicator was associated with the risk of both HPV-negative HNSCC [IVW OR (95% CI) = 2.59 (1.37, 4.92), P = 0.0004] and HPV-positive HNSCC [IVW OR (95% CI) = 2.6 (1.2, 5.65), P = 0.02]

Study a good start Both Maxwell and Hopfer agree that Hutchisons study was a quality study and a good start, but theyd like to see more research related to the long-term effects of marijuana use

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