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E-cigarettes and other related airway inflammatory diseases Allergic rhinitis (AR) is a chronic, non-infectious inflammatory disease of the nasal mucosa, primarily mediated by immunoglobulin E (IgE) in atopic individuals exposed to allergens [85]

Joossens and M

Bilbo Baggins (by Pauline Baynes) Back in the 1970s and 80s when one in four or five older men were still pipe smokers, they all carried a pouch somewhere on their persons, either a drug-store cellophane pack of Sail or some other OTC or, for the more serious, a leather roll up

The same study did find a statistically significant increased risk of stroke in never-smokers who used snus, so the cardiovascular profile for snus is far cleaner than cigarettes, but not a clean bill of health