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Clin Gastroenterol Hepatol 22(8):15861595 Saddique MN, Saleem S, Shahid I, Javid S, Khan MH, Iqbal J (2024) The estrogen-gallstone connection: uncovering the pathways

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Consider this example from the SEC, in which an investor makes a $100,000 initial investment that earns 4% a year for 20 years: An investor who pays a 0.25% annual fee versus one paying 1% a year would have roughly $30,000 more after two decades $208,000, versus $179,000.