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The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]

But Keller-Hamilton points out that nicotine is a "highly addictive substance." Regular users of nicotine can experience withdrawal symptoms, including irritability, cravings, anxiety, depression, sleep problems and increased appetite, according to the National Institute on Drug Abuse

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First, we investigated OXPHOS levels and observed that protein levels of Complex V F1 were not significantly different in PBECs from non-smokers compared to smokers