legal consequences of tobacco Support for control policies in states with smoking disparities Federal Tobacco Action Center |

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Tumour mutational burden LCINS generally have a markedly lower TMB (measured as non-synonymous mutations per megabase (mut/Mb)) in coding and non-coding regions compared to smoking-related lung cancers, with early studies suggesting as much as a tenfold difference 131 and a doseresponse relationship between TMB and pack-years 132 (Table 1)

Nicotine can temporarily enhance concentration and focus by stimulating the release of neurotransmitters like dopamine and acetylcholine, which play a role in attention and memory