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Treatment with FOXO4-DRI reduces hydroxyproline content in lung tissue, a direct measure of collagen deposition, and improves lung histology assessed by hematoxylin-eosin and Masson trichrome staining

Pfizer has unsuccessfully attempted to develop two GLP1RA drug candidates, lotiglipron (PF-07081532), co-developed with Heptares Therapeutics Ltd., and danuglipron (PF-06882961), both small molecules and new molecular entities intended for oral delivery for treatment of obesity