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Besides the above-identified risk factors for the two different kinds of esophageal cancers, extensive research has demonstrated the role of fungal species in the development of squamous cell carcinoma in immunodeficient patients suffering from auto-immune polyendocrinopathy candidiasis ectodermal dystrophy [APECED] [54], an autosomal recessive disorder caused by mutations in the autoimmune regulator gene, which encodes the nuclear transcription protein responsible for the induction of immunological self-tolerance [55, 56]