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The spectrum of peptide therapy ranges from major FDA-approved prescription drugs such as insulin and GLP-1 analogues used to treat diabetes and metabolic disorders, to specialized, off-label compounds for weight management
Studies show by inhibiting NNMT, the 5 amino compound prevents unnecessary methylation of nicotinamide, thus preserving NAD+ for energy metabolism
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Gianello (PubMed) Research Focus : Mechanistic Preclinical Research Title : Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug (Book chapter, Peptides: The Wave of the Future, APSY vol 7, 2001) Authors : Woei-Jia Jiang, Robert Gianello, Mark Heffernan, Esra Ogru, Roksan Libinaki, Frank Ng (SpringerLink) Research Focus : Preclinical Lipid Metabolism Studies (Mice) Title : The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and -AR knockout mice (Endocrinology, Dec 2001) Authors : M
