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These alterations may be further exacerbated by oxidative stress and activation of profibrotic cytokines, such as transforming growth factor , ultimately contributing to the development of chronic kidney disease (82)

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Safety concerns arise from kefirs microbial variability and lack of standardization, highlighting the need for clear regulatory guidelines (Metras et al., 2021)

Summary Keywords metabolite, biomarker, major depressive disorder, acetylcarnitine, remission status, drug treatment Citation Lee S, Mun S, Lee Y-R, Choi H, Joo E-J, Kang H-G and Lee J (2022) Discovery and validation of acetyl-L-carnitine in serum for diagnosis of major depressive disorder and remission status through metabolomic approach