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Reported Adverse Effects From the limited human studies and anecdotal reports from users, the following side effects have been documented: Injection site pain and local reactions Joint pain or exacerbation of existing joint discomfort Anxiety and mood disturbances Palpitations and cardiovascular symptoms Insomnia or sleep disruption Nausea and gastrointestinal discomfort The frequency and severity of these effects remain unclear because no systematic adverse effect monitoring has been conducted across a large human population

Using any enemas regularly for a long time can cause the bowel muscle to weaken, which is linked to constipation and inflammation of the bowel

Age-related macular degeneration masquerade: a review of pentosan polysulfate maculopathy and implications for clinical practice

Metabolome analysis confirmed that sulfasalazine treatment decreased glutathione and cysteine-glycine levels in the kidney (Figure 4H)