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doi: 10.1016/j.gene.2019.03.033 10 ChangKYangSMKimSHHanKHParkSJShinJI

To exclude that the observed metabolic phenotype was cell line specific, we validated the findings in two isogeneic spontaneously metastatic sublines, D2A1-m1 and D2A1-m2, generated from the poorly metastasizing murine-derived D2A1 cell line by serial in vivo passaging (Jungwirth et al, 2018)

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Hereditary glutathione reductase deficiency generally impairs cellular energy balance and increases the level of oxidative stress in red blood cells and has been related to hereditary hemolytic anemia 9,10