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Certain structures of the central nervous system will transform to accommodate the nicotine as a primary source of releasing dopamine, yet at the same time, the effects of nicotine will lessen, which creates the need to consume higher doses to get the same dopaminergic effects

CYP1A2, 2A6, 2C9, 2D6, 2E1, and 3A4 isoforms also play a role in the metabolism of bupropion, but to a lesser extent ( Oxidation of bupropion side chain results in the formation of a glycine conjugate of metachlorobenzoic acid, which is then excreted as the major urinary metabolite

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