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notably described that the substitution of the first 290 residues of MRP1 by the corresponding residues of MRP2, like in chimera M1, leads to a complete absence of addressing to the plasma membrane with a retention in the endoplasmic reticulum 19

Serum was separated by centrifugation and stored at 80C for biochemical analysis

Accumulation of compatible osmolytes (e.g., proline and soluble sugars), activation of enzymatic antioxidants (SOD, CAT, POD), synthesis of stress-responsive proteins, and abscisic acid (ABA)-mediated signaling collectively preserve cellular homeostasis (Table 1)

Potential Therapeutic Indications for Systemic Delivery: Immune Modulation: Stabilizing and supporting balanced immune responses Metabolic Enhancement: Assisting in energy balance and lean mass preservation