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The theoretical maximum amount in solution is determined by the relative amounts of its pH-dependent unprotonated and protonated forms and follows the Henderson-Hasselbalch and precipitation-pH (pHp) models ( Figures 3 , and S4, S5, in Supplemental Information )

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Drug metabolism, which primarily occurs in the liver, directly affects the plasma concentrations of various drugs and depends on the presence and activity of liver enzymes, particularly cytochrome P450 and monoamine oxidase 71

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