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Exp Clin Psychopharmacol 8 : 326332

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as a whole (based on observed consumption and smoking prevalence for the U.S.), the average smoker consumed 377.5 packs per year in 1995, and this volume has declined by nearly eight packs per year through 2006, as displayed in Figure 1.[] Given this close-to-linear trend in smoking intensity and the lack of data for this variable, we make some simplifying assumptions