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Studies have confirmed that cigarette extracts induce the conversion of macrophages to osteoclasts through the classic RANKL-RANK pathway, upregulate the expression of NFATc1, promote macrophage activation, and induce the expression of the osteoclastogenesis-related proteases TRAP, cathepsin K and MMP-9 (182)

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Regulatory Compliance In most countries, including Australia, strict laws govern cigarette sales

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Archived from the original on February 5, 2021

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