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Epub 2004 Feb 29

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

To assess retinal function, we performed electroretinography (ERG) recordings across a range of stimulus intensities

The disconnect between short plasma half-life and prolonged therapeutic effects observed in many studies supports tissue-level mechanisms extending beyond circulating peptide concentrations